Transcriptional response to the HSP70 inhibitor MAL3-101 in parental rhabdomyosarcoma cells and isogenic acquired-resistance lines.

ABSTRACT: We demonstrate that inhibition of HSP70 with MAL3-101 induces activation of the unfolded protein response, and that cells with acquired resistance upregulate a cytosolic HSP70 at the level of mRNA.

ORGANISM(S): Homo sapiens

PROVIDER: GSE80525 | GEO | 2016/05/15

SECONDARY ACCESSION(S): PRJNA319193

REPOSITORIES: GEO