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Epigenetic reprogramming in naïve CD4+ T cells favoring T cell activation and Th2 differentiation as an early event in lupus flares

ABSTRACT: Systemic lupus erythematosus is a relapsing autoimmune disease that affects multiple organ systems. T cells play an important role in the pathogenesis of lupus, however, early T cell events triggering disease flares are incompletely understood. We studied DNA methylation in naïve CD4+ T cells from lupus patients to determine if epigenetic landscape change in CD4+ T cells is an early event in lupus flares.

ORGANISM(S): Homo sapiens

PROVIDER: GSE80553 | GEO | 2017/04/10

SECONDARY ACCESSION(S): PRJNA319260

REPOSITORIES: GEO

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