Dataset Information


The human pericardial fluid is enriched with cardiovascular-expressed microRNAs

ABSTRACT: The pericardial fluid (PF) surrounds the heart and it is contained in the pericardial sac. PF contains myocardial-derived factors. MicroRNAs (miRNAs) are negative post-transcriptional regulators of their target genes and they can be released into extracellular vesicles (EVs) contributing to cell-to-cell communication. We hypothesize that the PF contains miRNAs of myocardial origin and that represents a niche for the exchange of miRNAs between heart cells. In order to investigate whether PF contains functionally active miRNAs, miRNA expression profiles on PF samples collected from three patients undergoing aortic valve replacement (AVR) surgery performed during cardiopulmonary-bypass (CPB), were genereted. Overall design: PF samples were collected from three patients undergoing aortic valve replacement (AVR) surgery performed during cardiopulmonary-bypass (CPB).

INSTRUMENT(S): Exiqon human V3 microRNA PCR panel I+II (PROBE_ID version)

SUBMITTER: Costanza Emanueli  

PROVIDER: GSE80577 | GEO | 2017-06-10



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Human Pericardial Fluid Contains Exosomes Enriched with Cardiovascular-Expressed MicroRNAs and Promotes Therapeutic Angiogenesis.

Beltrami Cristina C   Besnier Marie M   Shantikumar Saran S   Shearn Andrew I U AI   Rajakaruna Cha C   Laftah Abas A   Sessa Fausto F   Spinetti Gaia G   Petretto Enrico E   Angelini Gianni D GD   Emanueli Costanza C  

Molecular therapy : the journal of the American Society of Gene Therapy 20170201 3

The pericardial fluid (PF) is contained in the pericardial sac surrounding the heart. MicroRNA (miRNA) exchange via exosomes (endogenous nanoparticles) contributes to cell-to-cell communication. We investigated the hypotheses that the PF is enriched with miRNAs secreted by the heart and that it mediates vascular responses through exosome exchange of miRNAs. The study was developed using leftover material from aortic valve surgery. We found that in comparison with peripheral plasma, the PF contai  ...[more]

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