Ontology highlight
ABSTRACT:
INSTRUMENT(S): Exiqon human V3 microRNA PCR panel I+II (PROBE_ID version)
SUBMITTER: Costanza Emanueli
PROVIDER: GSE80577 | GEO | 2017-06-10
SECONDARY ACCESSION(S): PRJNA319341
REPOSITORIES: GEO
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Beltrami Cristina C Besnier Marie M Shantikumar Saran S Shearn Andrew I U AI Rajakaruna Cha C Laftah Abas A Sessa Fausto F Spinetti Gaia G Petretto Enrico E Angelini Gianni D GD Emanueli Costanza C
Molecular therapy : the journal of the American Society of Gene Therapy 20170201 3
The pericardial fluid (PF) is contained in the pericardial sac surrounding the heart. MicroRNA (miRNA) exchange via exosomes (endogenous nanoparticles) contributes to cell-to-cell communication. We investigated the hypotheses that the PF is enriched with miRNAs secreted by the heart and that it mediates vascular responses through exosome exchange of miRNAs. The study was developed using leftover material from aortic valve surgery. We found that in comparison with peripheral plasma, the PF contai ...[more]