Transcriptomics,Genomics

Dataset Information

19

Wildtype (N2) C. elegans: Control vs. 10mM LiCl treated for 48hr at 25oC


ABSTRACT: Transcriptional profiling of adult C. elegans comparing control untreated with populations exposed to 10mM LiCl. Populations treated from larval stage L4 for 48hr at 25oC. 10mM LiCl contained in the Nematode Growth Media (NGM) Keywords: Drug treatment Overall design: Two-condition experiment, Control vs. 10mM LiCl treated populations. Biological replicates: 6 control, 6 LiCl treated, independently grown and harvested. All samples compared against common reference total RNA from mixed stage wildtype (N2) worms. One replicate per array.

INSTRUMENT(S): GSC C.elegans 22.5K jan04

SUBMITTER: Gawain McColl   

PROVIDER: GSE8058 | GEO | 2007-12-01

SECONDARY ACCESSION(S): PRJNA100889

REPOSITORIES: GEO

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Publications

Pharmacogenetic analysis of lithium-induced delayed aging in Caenorhabditis elegans.

McColl Gawain G   Killilea David W DW   Hubbard Alan E AE   Vantipalli Maithili C MC   Melov Simon S   Lithgow Gordon J GJ  

The Journal of biological chemistry 20071024 1


Lithium (Li(+)) has been used to treat mood affect disorders, including bipolar, for decades. This drug is neuroprotective and has several identified molecular targets. However, it has a narrow therapeutic range and the one or more underlying mechanisms of its therapeutic action are not understood. Here we describe a pharmacogenetic study of Li(+) in the nematode Caenorhabditis elegans. Exposure to Li(+) at clinically relevant concentrations throughout adulthood increases survival during normal  ...[more]

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