Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Circulating microRNAs and life expectancy among identical twins

ABSTRACT: Objective: To characterize miRNAs in 41-year archived plasma in relation to life expectancy independent of genes. Method: Plasma miRNAs from nine identical male twins were profiled using next-generation sequencing. Results: The average absolute difference in the minimum life expectancy was 9.68 years. Intra-class correlation coefficients were above 0.4 for 50% of miRNAs. Comparing deceased twins with their alive co-twin brothers, the concentrations were increased for 34 but decreased for 30 miRNAs. Conclusion: Identical twins discordant in life expectancy were unlike in the majority of miRNAs, suggesting that environmental factors are pivotal in miRNAs related to life expectancy.

ORGANISM(S): Homo sapiens

PROVIDER: GSE80730 | GEO | 2016/12/30

SECONDARY ACCESSION(S): PRJNA319821

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

Homo sapiens

Project description:Circulating microRNAs and life expectancy among identical twins

| PRJNA319821 | ENA

Epigenome analysis of female identical twins

Project description:Genome wide DNA methylation profiling of blood samples from eight female identical twins of Han Chinese for forensic age prediction, age 21 to 32. The Illumina Infinium HumanMethylation450 BeadChip was used to obtain DNA methylation profiles across approximately 485,000 CpGs at a single-nucleotide resolution. Samples included 8 pairs of identical female twins of Han Chinese.

2015-12-08 | GSE65638 | GEO

Epigenome analysis of female identical twins

2015-12-08 | E-GEOD-65638 | biostudies-arrayexpress

Epigenome analysis of male identical twin pairs discordant for sexual orientation, age 21 to 55.

Project description:Genome wide DNA methylation profiling of saliva samples from male identical twins discordant for sexual orientation, age 21 to 55. The Illumina Infinium 27k Human DNA methylation Beadchip v1.2 was used to obtain DNA methylation profiles across approximately 27,000 CpGs in bisulfite converted DNA. Samples included 34 pairs of identical twins and one set of identical triplets, and 13 hybridisations were technical replicates of a selection of those samples.

2011-04-21 | GSE28746 | GEO

Epigenome analysis of male identical twin pairs discordant for sexual orientation, age 21 to 55.

2011-04-21 | E-GEOD-28746 | biostudies-arrayexpress

Integrative Omics Studies on Identical Twins with and without Asthma

Project description:Integrative Omics Studies on Identical Twins with and without Asthma

| PRJNA278912 | ENA

Genome-wide DNA methylation profiling in anorexia nervosa discordant identical twins

Project description:Genome-wide DNA methylation profiling in anorexia nervosa discordant identical twins

| PRJNA775991 | ENA

Large-scale non-targeted serum metabolomics in the Swedish Twin Registry

Project description:The TwinGene project, conducted between 2004 and 2008, is a population-based Swedish study of twins born between 1911 and 1958. The study participants have previously participated in a telephone interview called Screening Across the Lifespan Twin Study, conducted between 1998 and 2002. To be included in TwinGene, both twins within a pair had to be alive. In total, 12591 individuals participated by donating blood to the study, and by answering questionnaires about life style and health. For the purpose of metabolomic profiling, we designed a case-cohort of incident coronary heart disease, diabetes, dementia and ischemic stroke events and a matched sub-cohort (controls) stratified on age and sex. In the final analysis we included serum samples from 2,139 individuals.

2014-08-30 | MTBLS93 | MetaboLights

miRNA profiling of HPCX1 linked prostate cancer patients and their healthy brothers

Project description:MicroRNA expression levels in the lymphoblastic cells of prostate cancer patients and their healthy brothers from HPCX1 linked prostate cancer families were analyzed to trace variants that might alter miRNA expression and explain partly an inherited genetic predisposion to prostate cancer. MicroRNA expression levels in lymphoblastoid cell lines were detected using an Agilent Human miRNA V2 Oligo Microarray Kit (Agilent Technologies).100 ng of total RNA was used as a starting material, and miRNAs were labeled using the Agilent miRNA Labeling Kit. Labeled RNA was hybridized to Agilent miRNA arrays with eight identical arrays per slide, with each array containing probes directed against 723 human and 76 human viral miRNAs. Slides were scanned (Agilent microarray scanner) after hybridization and data was extracted using Feature Extraction software, version 9.5.1. (Agilent Technologies). Altogether 14 cancer patients and 15 healthy brothers from 11 families were included with no replicates.

2011-12-31 | E-GEOD-24201 | biostudies-arrayexpress

Homo sapiens

Project description:TCR repertoire of identical twins study

| PRJNA329041 | ENA