Gene regulation of candidate cancer gene DIP2C
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ABSTRACT: Purpose: The disco-interacting protein 2 homolog C (DIP2C) gene is an uncharacterized gene found mutated in breast and lung cancers. We want to understand the role of DIP2C in tumor development. Methods: We engineered human DIP2C knockout cell systems by genome editing, and then use next-generation sequencing to identify the genes affected by the loss of DIP2C. Results: Inactivation of DIP2C triggers substantial gene expression changes, cellular senescence and epithelial to mesenchymal transition in cancer cells.
ORGANISM(S): Homo sapiens
PROVIDER: GSE80746 | GEO | 2017/07/31
SECONDARY ACCESSION(S): PRJNA319905
REPOSITORIES: GEO
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