Transcriptomics,Genomics

Dataset Information

29

Gene expression profiling of the prostate cancer cell line PC3.


ABSTRACT: To study the effect of miR-130a in prostate cancer, PC3 cells overexpressing miR-130a were analyzed for global gene expression. Overall design: PC3 cells were transfected with miR-130a or negative control in three independent experiments.

INSTRUMENT(S): [HTA-2_0] Affymetrix Human Transcriptome Array 2.0 [transcript (gene) version]

SUBMITTER: Anita Sveen  

PROVIDER: GSE80750 | GEO | 2017-03-10

SECONDARY ACCESSION(S): PRJNA319927

REPOSITORIES: GEO

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Publications


MicroRNAs (miRNAs) are small, non-coding RNAs that mediate post-transcriptional gene silencing, fine tuning gene expression. In an initial screen, miRNAs were found to be globally down-regulated in prostate cancer (PCa) cell lines and primary tumours. Exposure of PCa cell lines to a demethylating agent, 5-Aza-CdR resulted in an increase in the expression levels of miRNAs in general. Using stringent filtering criteria miR-130a was identified as the most promising candidate and selected for valida  ...[more]

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