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Gene expression analysis in lung fibroblasts from p38+/+ (wt) and p38ki/ki (ki) mice

ABSTRACT: To assess differently expressed genes beween wt and ki fibroblasts

ORGANISM(S): Mus musculus

PROVIDER: GSE80825 | GEO | 2016/06/01

SECONDARY ACCESSION(S): PRJNA320087

REPOSITORIES: GEO

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Gene expression analysis in lung fibroblasts from p38+/+ (wt) and p38ki/ki (ki) mice

Project description:To assess differently expressed genes beween wt and ki fibroblasts Total RNA was purified from fibroblasts of 3 different mice for wt and 3 different mice for ki

2016-06-01 | E-GEOD-80825 | biostudies-arrayexpress

RNA sequencing of Normal Human Fibroblasts and Patient Fibroblasts with Novel SCP2 Variant

Project description:The purpose of this study was to identify differentially expressed genes beween normal and SCP2 mutant fibroblasts

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Gene regulation in ki-ras transfected murine fibroblasts

Project description:Ki-ras gene mutations are involved in the carcinogenesis of acute myeloid leukemia, melanoma and different carcinomas. In order to define potential mutation-specific therapeutic targets, expression profiling analyses were performed using stable transfected NIH3T3 cells carrying different ki-ras gene mutations. Maybe, this analysis allows the discorvery of ras-associated cellular mechanisms, which might lead to the identification of physiological targets for pharmacological interventions of the treatment of Ki-ras-associated human tumors. Keywords: cDNA microarray, murine fibroblast, ki-ras mutations, carcinogenesis

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Gene regulation in ki-ras transfected murine fibroblasts

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10X genomic single cell RNA-seq of WT and p47phox-KI lungs with acute lung injury

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Murine colonic epithelial cells: Trabid(Zranb1) C443S hetero knock-in mouse (KI/+) vs. homo knock-in mouse (KI/KI)

Project description:Transcriptional profiling of colonic epithelial cells comparing control Trabid KI/+ with KI/KI

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Ad-HER-wt and Ad-HER2-ki infected HMECs

Project description:As an oncogene, use of HER2 vaccines in humans requires the development of HER2 immunotherapies with maximal immunologic potential, but minimal oncologic potential. To address these issues, we developed a recombinant adenoviral vector expressing a mutated HER2 inactivated for kinase function (Ad-HER2-ki). Ad-HER2-ki was highly expressed, but non-phosphorylated and elicited minimal transcription dysregulation in primary cells. In contrast, Ad-HER2-wt elicited a strong oncogenic signature associated with tumorigenesis.

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Ki-67 organises heterochromatin during cell proliferation

Project description:Antigen Ki-67 is a nuclear protein expressed in proliferating mammalian cells. It is widely used in cancer histopathology but its functions remain unclear. Here, we show that Ki-67 controls heterochromatin organisation. Altering Ki-67 expression levels did not significantly affect cell proliferation in vivo. Ki-67 mutant mice developed normally and cells lacking Ki-67 proliferated efficiently. Conversely, upregulation of Ki-67 expression in differentiated tissues did not inhibit cell cycle arrest. Ki-67 interactors included proteins involved in nucleolar processes and chromatin regulators. Ki-67 depletion disrupted nucleologenesis but did not inhibit pre-rRNA processing. In contrast, it altered gene expression. Ki-67 silencing also had wide-ranging effects on chromatin organisation, disrupting heterochromatin compaction and long-range genomic interactions. Trimethylation of histone H3K9 and H4K20 at heterochromatin was strongly reduced. Overexpression of human or Xenopus Ki-67 induced ectopic heterochromatin formation. Altogether, our results suggest that Ki-67 expression in proliferating cells spatially organises heterochromatin, thereby controlling gene expression.

2018-10-26 | PXD003551 | Pride

RNA-seq of Setx KI and WT Spinal Cord

Project description:The goal of this study is to compare differences in splicing between bulk spinal cord samples isolated from Setx KI and WT mice

2022-04-22 | GSE199664 | GEO

Human HeLa cells: Control shRNA vs Ki-67 shRNA, in vitro and xenografts

Project description:Transcriptional profiling of isogenic human cervical cancer cell line HCT-116, comparing cells treated with control shRNA or with Ki-67 shRNA, grown either in vitro or as tumours in nude mice. The aim was to assess effects of loss of Ki-67 on gene expression during exponential cell growth and in tumours

2021-02-18 | GSE162365 | GEO

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