Genomics

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Temporal Gene Expression Profiling of Astrocyte Precursors During Development


ABSTRACT: Lineage development is a step-wise process, governed by stage-specific regulatory factors and associated markers. Astrocytes are one of the principle cell types in the CNS and the stages associated with their development remain very poorly defined. To identify these stages we performed gene expression profiling on astrocyte precursor populations in the spinal cord, identifying distinct patterns of gene induction during their development. Validation studies identified a new cohort of astrocyte-associated genes during development and demonstrated their expression in reactive astrocytes in human white matter injury (WMI).

ORGANISM(S): Mus musculus

PROVIDER: GSE80826 | GEO | 2016/12/16

SECONDARY ACCESSION(S): PRJNA320093

REPOSITORIES: GEO

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