Project description:Analysis of the different genotypes of non-tumorous mouse livers in 3 different ages revealed more genetic alterations in Krt18-/- and Krt18+/- compared to wt livers. This speaks in favor of a higher genomic instability being causally related to K-deficiency and aging, even at a preneoplastic stage.
Project description:Analysis of the different genotypes of non-tumorous mouse livers in 3 different ages revealed more genetic alterations in Krt18-/- and Krt18+/- compared to wt livers. This speaks in favor of a higher genomic instability being causally related to K-deficiency and aging, even at a preneoplastic stage.
Project description:Analysis of the different genotype tumors revealed enhanced chromosomal aberrations in all tumors. The most chromosomal aberrations were found in the krt18-/- tumors.
Project description:Analysis of the different genotype tumors revealed enhanced chromosomal aberrations in all tumors. The most chromosomal aberrations were found in the krt18-/- tumors. Two-condition experiment: wt (non-affected) liver tissue vs. wt tumor / krt18+/-tumor / krt18-/- tumor
Project description:This SuperSeries is composed of the following subset Series: GSE23352: Whole-genome gene expression profiles of non-tumorous human lung tissues: Laval set GSE23529: Whole-genome gene expression profiles of non-tumorous human lung tissues: UBC set GSE23545: Whole-genome gene expression profiles of non-tumorous human lung tissues: GRNG set Refer to individual Series