Transcriptomics,Genomics

Dataset Information

93

FOXO1 is an oncogenic mediator in AML1-ETO leukemia


ABSTRACT: Transcriptome analysis by RNAseq of human CD34+ hematopoietic stem and progenitor cells transduced with empty vector control(MIT), AML1-ETO (AE), wildtype FOXO1 (F WT) or FOXO1 DNA binding deficient mutant (F DB). We find wildtype FOXO1 partially recapitulates gene signature of AML1-ETO Overall design: Human CD34+ hematopoietic stem and progenitor cells from three donors were transduced with retrovirus expressing MIT, AE, F WT or F DB. Transduced cells were sorted at day 5 after transduction, RNA was collected for RNAseq.

INSTRUMENT(S): Illumina HiSeq 1000 (Homo sapiens)

SUBMITTER: Shan Lin 

PROVIDER: GSE81084 | GEO | 2017-12-15

SECONDARY ACCESSION(S): PRJNA320467

REPOSITORIES: GEO

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