RIP4 inhibits STAT3 Signaling to sustain Lung Adencarcinoma Differentiation

ABSTRACT: Evaluation of the role of RIP4 in lung adenocarcinoma revealed that RIP4 inhibits STAT3 signaling in vitro and in vivo. Repression of RIP4 enhanced STAT3 signaling activation in KRAS LSL/G12D/wt; p53flox/flox murine tumors. This promoted cancer dedifferentiation through ECM remodeling

ORGANISM(S): Mus musculus

PROVIDER: GSE81154 | GEO | 2016/06/30

SECONDARY ACCESSION(S): PRJNA320749

REPOSITORIES: GEO