Inhibition of adhesion molecule gene expression and cell adhesion by the metabolic regulator PGC-1alpha

ABSTRACT: Cell adhesion plays an important role in determining cell shape and function in a variety of physiological and pathophysiological conditions. While links between metabolism and cell adhesion were previously suggested, the exact context and molecular details of such a cross-talk remain incompletely understood. Our study shows that PGC-1alpha, a pivotal transcriptional co-activator of metabolic gene expression, acts to inhibit expression of cell adhesion genes. Using cell lines as well as primary cells, we show that both endogenous and exogenous PGC-1a down-regulate expression of a variety of cell adhesion molecules.

OTHER RELATED OMICS DATASETS IN: PRJNA320774

ORGANISM(S): Mus musculus Homo sapiens

PROVIDER: GSE81171 | GEO | 2017/01/17

SECONDARY ACCESSION(S): PRJNA320774

REPOSITORIES: GEO