Transcriptomics,Genomics

Dataset Information

50

Transcriptional profiling of CD4+ T cells activated in murine malaria.


ABSTRACT: CD4+ T cells are critical for defense against the Plasmodium parasites that cause malaria. To better understand CD4+ T cell effector mechanisms during malaria, we performed microarray analysis of CD4+ T cells from naïve and infected mice. Comparison of activated (CD44 hi CD62L lo) CD4+ T cells from infected mice to bulk CD4+ T cells from naïve mice revealed a subset of genes that were upregulated by infection with Plasmodium chabaudi. These results help generate a more complete picture of CD4+ T cell function in malaria. Overall design: Total CD4+ T cells were double-sorted from the blood of adult naïve female mice; activated (CD44 hi CD62L lo) CD4+ T cells were double-sorted from the blood of adult female mice 6 d post-infection with P. chabaudi. Four independent biological replicates were performed per condition.

INSTRUMENT(S): Agilent-028005 SurePrint G3 Mouse GE 8x60K Microarray (Feature Number version)

SUBMITTER: Charlie Kim  

PROVIDER: GSE81196 | GEO | 2016-11-12

SECONDARY ACCESSION(S): PRJNA320886

REPOSITORIES: GEO

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