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FOXR2 Interacts with MYC to Promote Its Transcriptional Activities and Tumorigenesis

ABSTRACT: Combining the results of a large scale proteomic analysis of human transcription factor interaction network with knowledge databases, we identified FOXR2 as one of the top-ranked candidate proto-oncogenes. Here, we show that FOXR2 forms a stable complex with MYC and MAX and subsequently regulates cell proliferation by promoting MYC’s transcriptional activities. We demonstrated that FOXR2 is highly expressed in several breast, lung, and liver cancer cell lines and related patient tumor samples, while reduction of FOXR2 expression in a xenograft model inhibits tumor growth. These results indicate that FOXR2 acts with MYC to promote cancer cell proliferation, which is a potential tumor-specific target for therapeutic intervention against MYC-driven cancers.

ORGANISM(S): Homo sapiens

PROVIDER: GSE81381 | GEO | 2017/02/17

SECONDARY ACCESSION(S): PRJNA321408

REPOSITORIES: GEO

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| S-EPMC4946253 | biostudies-literature

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