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Acetylation enhances TET2 function in protecting against abnormal DNA methylation during oxidative stress

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Homo sapiens

PROVIDER: GSE81428 | GEO | 2016/12/31

SECONDARY ACCESSION(S): PRJNA321516

REPOSITORIES: GEO

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Similar Datasets

Acetylation Enhances TET2 Function in Protecting against Abnormal DNA Methylation during Oxidative Stress.

Project description: Not available

| S-EPMC5260804 | biostudies-literature

Acetylation enhances TET2 function in protecting against abnormal DNA methylation during oxidative stress [A2780 TET2 KO - methylation]

Project description:Genome wide DNA methylation profiling of A2780 control cells (Scr_1 and Scr_2), and A2780 TET2 KO clones (KO1.1, KO1.36, and KO2.32). The Illumina’s Infinium Human Methylation450 Beadchip Kit (WG-314-1001) was used to obtain DNA methylation profiles across approximately 450,000 CpGs.

2016-12-31 | GSE83751 | GEO

Acetylation enhances TET2 function in protecting against abnormal DNA methylation during oxidative stress [gene expression]

Project description:Transcriptional profiling of A2780 cells with genetic TET2 knockout, generated by CRISPR. The aim was to identify genes affected by TET2 KO. Three individual KO clones were profiled. Control cells were cells that infected with control sgRNA.

2016-12-31 | GSE79808 | GEO

Acetylation enhances TET2 function in protecting against abnormal DNA methylation during oxidative stress [shTET2 - H2O2 - methylation]

Project description:Genome wide DNA methylation profilings (Bisulfite (BS), or oxidative bisulfite (oxBS)) were done for A2780 cells 1) infected with control virus, no H2O2 (Scr_mock) treatment, 2) infected with control virus with H2O2 treatment (30 min plus 2.5 h resting) (Scr_H2O2), and 3) infected with shTET2 virus, with H2O2 treatment (30 min plus 2.5 h resting) (shTET2_H2O2). Each genomic DNA was splitted equally to two aliquots. One aliquote was subjected to oxidation (oxBS) and one to mock oxidation (BS) prior to bisulfite treatment (CEGX protocol). The Illumina’s Infinium Human Methylation450 Beadchip Kit (WG-314-1001) was used to obtain DNA methylation profiles across approximately 450,000 CpGs. 5hmC levels were calculated by subtracting oxBS values from BS values.

2016-12-31 | GSE83750 | GEO

Acetylation enhances TET2 function in protecting against abnormal DNA methylation during oxidative stress [A2780 TET2KD damage 3h - methylation]

Project description:Genome wide DNA methylation profiling of A2780 cells 1) infected with control virus, no H2O2 (Scr_mock), 2) infected with control virus with H2O2 treatment (30 min plus 2.5 h resting) (Scr_H2O2), 3) infected with shTET2 virus, no H2O2 (shTET2_mock), and 4) infected with shTET2 virus, with H2O2 treatment (30 min plus 2.5 h resting) (shTET2_H2O2, two biological replicates). The Illumina’s Infinium Human Methylation450 Beadchip Kit (WG-314-1001) was used to obtain DNA methylation profiles across approximately 450,000 CpGs.

2016-12-31 | GSE81427 | GEO

Acetylation enhances TET2 function in protecting against abnormal DNA methylation during oxidative stress [A2780 damage time points - methylation]

Project description:Genome wide DNA methylation profiling of A2780 cells untreated (mock), treated with H2O2 for 30 min (H2O2 30 min), or treated with H2O2 for 30 min with additional 2.5 hour resting ( H2O2 3h) . The Illumina’s Infinium Human Methylation450 Beadchip Kit (WG-314-1001) was used to obtain DNA methylation profiles across approximately 450,000 CpGs.

2016-12-31 | GSE81426 | GEO

Acetylation enhances TET2 function in protecting against abnormal DNA methylation during oxidative stress

Project description:Acetylation enhances TET2 function in protecting against abnormal DNA methylation during oxidative stress

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Nucleoredoxin guards against oxidative stress by protecting antioxidant enzymes.

Project description: Not available

| S-EPMC5547615 | biostudies-literature

PaCATB, a secreted catalase protecting Podospora anserina against exogenous oxidative stress.

Project description: Not available

| S-EPMC3184978 | biostudies-literature

Nucleoredoxin Guards against Oxidative Stress by Protecting Antioxidant Enzymes

Project description:Target capture by NRX1, NRX1(C58,378S) containing columns versus a control column. Recombinant NRX1 and mutant NRX1(C58,378S) proteins were immobilised on NHS-activated beads. Proteins were extracted from Arabidopsis plants treated for 24hrs with Pseudomonas syringae ES4326 and put through the columns. Proteins were eluted from columns using DTT.

2016-12-18 | MSV000080429 | MassIVE

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