Splicing towards noncoding isoforms in colorectal carcinoma is associated with tumor hypoxia and the DNA damage response

ABSTRACT: Tumor hypoxia is associated with poor patient outcome and resistance to therapy. It is associated with a rapid decline in protein production mediated through mTOR signalling. Here we show that it also leads to widespread changes in splicing and a global shift towards the expression of noncoding isoforms, thus providing a novel and orthogonal mechanism by which cells can modulate protein expression.

ORGANISM(S): Homo sapiens

PROVIDER: GSE81513 | GEO | 2016/07/28

SECONDARY ACCESSION(S): PRJNA321835

REPOSITORIES: GEO