Transcriptomics,Genomics

Dataset Information

40

Human ECFCs: Cord Blood vs Peripehral Blood ECFCs


ABSTRACT: miRNA profiling was carried out using the miRCURY LNA™ microRNA Array (5th gen - hsa, mmu & rno). microRNA profiling of CB and PB-derived ECFCs from 3 independent donors from each cell source. To identify and understand the regulation of endothelial cell functions through comparing miRNA expression profiling of cord blood (CB) derived endothelial colony forming cells (ECFCs) and peripheral blood (PB) ECFCs Overall design: Two condition experiment, CB vs PB-derived ECFCs. 3 independent donors per ECFC source.

INSTRUMENT(S): miRCURY LNA™ microRNA Array (5th gen - hsa, mmu & rno) [miRBase version 15.0 + miRPlus]

SUBMITTER: Cheen Khoo 

PROVIDER: GSE81574 | GEO | 2017-03-20

SECONDARY ACCESSION(S): PRJNA322029

REPOSITORIES: GEO

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Publications

miR-193a-3p interaction with HMGB1 downregulates human endothelial cell proliferation and migration.

Khoo Cheen P CP   Roubelakis Maria G MG   Schrader Jack B JB   Tsaknakis Grigorios G   Konietzny Rebecca R   Kessler Benedikt B   Harris Adrian L AL   Watt Suzanne M SM  

Scientific reports 20170309


Circulating endothelial colony forming cells (ECFCs) contribute to vascular repair where they are a target for therapy. Since ECFC proliferative potential is increased in cord versus peripheral blood and to define regulatory factors controlling this proliferation, we compared the miRNA profiles of cord blood and peripheral blood ECFC-derived cells. Of the top 25 differentially regulated miRNAs selected, 22 were more highly expressed in peripheral blood ECFC-derived cells. After validating candid  ...[more]

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