Transcriptomics,Genomics

Dataset Information

43

Circulating miR-223 in Oral Cancer: Its Potential as a Novel Diagnostic Biomarker and Therapeutic Target


ABSTRACT: The current study used an ultra-sensitive genome-wide miRNA array to investigate changes in circulating miRNAs in plasma from patients with oral cancer and healthy individuals. Results indicated that there were only a few circulating miRNAs, including miR-223, miR-26a, miR-126, and miR-21, that were up-regulated in patients with oral cancer. A subsequent validation test indicated that circulating miR-223 levels were significantly higher (~2-fold, P< 0.05) in patients with oral cancer than in those without cancer. Moreover, in vitro studies revealed that miR-223 functions as a tumor suppressor. Overall design: Circulating levels of a total of 1,211 genome-wide miRNAs were measured with a microarray assay using pooled plasma samples from 5 patients with gingival squamous cell carcinoma (GSCC) and pooled normal plasma samples from 10 age- and sex-matched healthy controls. The circulating miRNA profile for patients with oral cancer was compared with that for controls.

INSTRUMENT(S): 3D-Gene Human miRNA V16_1.0.0

SUBMITTER: Satoshi Kondo  

PROVIDER: GSE81828 | GEO | 2017-02-11

SECONDARY ACCESSION(S): PRJNA322641

REPOSITORIES: GEO

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Publications

Circulating miR-223 in Oral Cancer: Its Potential as a Novel Diagnostic Biomarker and Therapeutic Target.

Tachibana Hirohiko H   Sho Ri R   Takeda Yuji Y   Zhang Xuhong X   Yoshida Yukie Y   Narimatsu Hiroto H   Otani Katsumi K   Ishikawa Shigeo S   Fukao Akira A   Asao Hironobu H   Iino Mitsuyoshi M  

PloS one 20160721 7


Circulating microRNAs (miRNAs) have been detected in various types of cancer and have been proposed as novel biomarkers for diagnosis and treatment. Until recently, however, no studies had comprehensively examined circulating miRNAs in oral cancer. The current study used an ultra-sensitive genome-wide miRNA array to investigate changes in circulating miRNAs in plasma from five patients with oral cancer and ten healthy individuals. Results indicated that there were only a few circulating miRNAs,  ...[more]

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