Ontology highlight
ABSTRACT:
INSTRUMENT(S): Illumina HiSeq 2000 (Mus musculus)
SUBMITTER: Erica Korb
PROVIDER: GSE81911 | GEO | 2017-08-18
SECONDARY ACCESSION(S): PRJNA323399
REPOSITORIES: GEO
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Korb Erica E Herre Margaret M Zucker-Scharff Ilana I Gresack Jodi J Allis C David CD Darnell Robert B RB
Cell 20170817 6
Fragile X syndrome (FXS) is a leading genetic cause of intellectual disability and autism. FXS results from the loss of function of fragile X mental retardation protein (FMRP), which represses translation of target transcripts. Most of the well-characterized target transcripts of FMRP are synaptic proteins, yet targeting these proteins has not provided effective treatments. We examined a group of FMRP targets that encode transcriptional regulators, particularly chromatin-associated proteins. Los ...[more]