Genomics

Dataset Information

53

ChIP-sequencing of histone marks in WT and Fmr1-/- (KO) neurons and mice


ABSTRACT: Widespread misregulation of histone modifcations occur in FXS, most notably increases in marks associated with active transcription. Overall design: 7DIV cultured cortical neurons from WT or Fmr1 KO mice were processed for H3K4me3 and H3K27ac ChIP. In addition, neurons sorted from cerebellar tissue from WT and Fmr1 KO BAC-TRAP NeuroD1 P15 mice were used for H3K4me3 ChIP, performed in triplicate

INSTRUMENT(S): Illumina HiSeq 2000 (Mus musculus)

SUBMITTER: Erica Korb 

PROVIDER: GSE81911 | GEO | 2017-08-18

SECONDARY ACCESSION(S): PRJNA323399

REPOSITORIES: GEO

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Publications

Excess Translation of Epigenetic Regulators Contributes to Fragile X Syndrome and Is Alleviated by Brd4 Inhibition.

Korb Erica E   Herre Margaret M   Zucker-Scharff Ilana I   Gresack Jodi J   Allis C David CD   Darnell Robert B RB  

Cell 20170817 6


Fragile X syndrome (FXS) is a leading genetic cause of intellectual disability and autism. FXS results from the loss of function of fragile X mental retardation protein (FMRP), which represses translation of target transcripts. Most of the well-characterized target transcripts of FMRP are synaptic proteins, yet targeting these proteins has not provided effective treatments. We examined a group of FMRP targets that encode transcriptional regulators, particularly chromatin-associated proteins. Los  ...[more]

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