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Neuronal activity modifies the chromatin accessibility landscape in the adult brain (ATAC-Seq OE)

ABSTRACT: We generated the chromatin accessibility profiling datasets from adult mouse dentate gyrus with cFos knockdown and overexpression upon neuronal activation (E0 and E1)

ORGANISM(S): Mus musculus

PROVIDER: GSE82011 | GEO | 2017/01/08

SECONDARY ACCESSION(S): PRJNA323616

REPOSITORIES: GEO

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Neuronal activity modifies the chromatin accessibility landscape in the adult brain (ATAC-Seq KD)

Project description:We generated the chromatin accessibility profiling datasets from adult mouse dentate gyrus with cFos knockdown upon neuronal activation (E0 and E1)

2017-01-08 | GSE82012 | GEO

Neuronal activity modifies the chromatin accessibility landscape in the adult brain (RNA-Seq OE)

Project description:We generated RNA profiling datasets from adult mouse dentate gyrus with cFos knockdown and/or overexpression upon neuronal activation

2017-01-08 | GSE82014 | GEO

Neuronal activity modifies the chromatin accessibility landscape in the adult brain (RNA-Seq)

Project description:We generated RNA profiling datasets from adult mouse dentate gyrus upon neuronal activation at three different time point

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Neuronal activity modifies the chromatin accessibility landscape in the adult brain (ATAC-Seq)

Project description:We generated the chromatin accessibility profiling datasets from adult mouse dentate gyrus upon neuronal activation at 3 different time points

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Neuronal activity modifies the chromatin accessibility landscape in the adult brain (RNA-Seq WT)

Project description:We generated RNA profiling datasets from adult mouse dentate gyrus upon neuronal activation at three different time point

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Project description:We generated the chromatin accessibility profiling datasets from adult mouse dentate gyrus upon neuronal activation at 3 different time points

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Neuronal activity modifies the chromatin accessibility landscape in the adult brain.

Project description: Not available

| S-EPMC5325677 | biostudies-literature

Effect of repeated optogenetic stimulation on chromatin accessibility in the mouse dentate gyrus [ATAC-seq]

Project description:To investigate the effect of repeated neural overactivation in the chromatin accessibility of dentate gyrus neurons, we optogenetically stimulated mouse dentate gyrus repeatedly.

2023-03-31 | GSE227201 | GEO

Neuronal activity-related transcription is blunted in immature compared to mature dentate granule cells

Project description:Immature dentate granule cells (DGCs) generated in the hippocampus during adulthood are believed to play a unique role in dentate gyrus function. Although immature DGCs have hyperexcitable membrane properties in vitro, the consequences of this hyperexcitability in vivo remain unclear. In particular, the relationship between experiences that activate the dentate gyrus, such as exploration of a novel environment (NE), and downstream molecular processes that modify dentate gyrus circuitry in response to cellular activation are unknown in this cell population. We first performed quantification of immediate early gene proteins in immature (5-week-old) and mature (13-week-old) DGCs from mice exposed to a NE. Paradoxically, we observed lower immediate early gene protein expression in hyperexcitable immature DGCs. We then isolated nuclei from active and inactive immature DGCs and performed single nuclei RNA-Sequencing. Compared to mature nuclei collected from the same animal, immature DGC nuclei showed less activity-induced transcriptional change, even though they were classified as active based on expression of ARC protein. These results demonstrate that the coupling of spatial exploration, cellular activation, and transcriptional change differs between immature and mature DGCs, with blunted activity-induced changes in immature cells.

2023-02-23 | GSE214309 | GEO

Effect of repeated optogenetic stimulation on gene expression in the mouse dentate gyrus [RNA-seq]

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