Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

An NF-κB-dependent, lineage-specific transcriptional program regulates Treg identity and function [RNA-seq]

ABSTRACT: We found a NF-κB-dependednt transcriptional program specific in Treg cells compared to Tconv cells by performing multiple RNAseq analyses using various knockout systems.

ORGANISM(S): Mus musculus

PROVIDER: GSE82076 | GEO | 2017/09/13

SECONDARY ACCESSION(S): PRJNA323927

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

An NF-kB-dependent, lineage specific transcriptional program regulates Treg identity and function [ChIP-seq]

Project description:NF-kB p65 ChIPseq revealed differential binding of p65 in Treg vs Tconv upon TCR stimulation

2017-09-13 | GSE99319 | GEO

An NF-κB-dependent, lineage-specific transcriptional program regulates Treg identity and function

Project description:An NF-κB-dependent, lineage-specific transcriptional program regulates Treg identity and function

| PRJNA323925 | ENA

An NF-κB-dependent, lineage-specific transcriptional program regulates Treg identity and function

Project description:An NF-κB-dependent, lineage-specific transcriptional program regulates Treg identity and function

| PRJNA407778 | ENA

An NF-κB-dependent, lineage-specific transcriptional program regulates Treg identity and function

Project description:This SuperSeries is composed of the SubSeries listed below.

2017-09-18 | GSE82078 | GEO

NF-κB transcription factors RelA and c-Rel selectively control CD4+ T-cell function in multiple sclerosis and cancer [bulk_mouse]

Project description:The outcome of cancer and autoimmunity is dictated by the recruitment and effector functions of CD4+ conventional T cells (Tconv cells). The NF-kappaB (NF-κB) family of transcription factors is implicated in different aspects of Tconv cell biology, but the cell-autonomous roles of NF-κB subunits are elusive. Here, we explored the contributions of canonical RelA and c-Rel subunits to Tconv function in health and disease. We found that RelA, rather than c-Rel, shaped the transcriptome of mouse and human Tconv cells at steady-state and was required for Tconv polarization toward the TH17 lineage in vitro. RelA-deficient mice were fully protected against neuro-inflammation in a mouse model of multiple sclerosis (MS), because of defective transition to a pathogenic TH17 gene expression program. In contrast, Tconv-restricted ablation of c-Rel, but not RelA, impaired their function in the microenvironment of transplanted tumors, resulting in enhanced cancer burden. c-Rel in Tconv cells was required for the response to PD-1-blockade therapy, and a c-Rel-dependent gene signature was correlated with better response and prognosis in anti-PD-1-treated patients. Our data demonstrate a division of labor between different subunits of the NF-κB pathway, paving the way for subunit-targeted immunotherapies.

2024-03-28 | GSE239700 | GEO

NF-κB transcription factors RelA and c-Rel selectively control CD4+ T-cell function in multiple sclerosis and cancer [bulk_human]

2024-03-28 | GSE239698 | GEO

NF-κB transcription factors RelA and c-Rel selectively control CD4+ T-cell function in multiple sclerosis and cancer [sc_rna]

2024-03-28 | GSE239703 | GEO

miRNA expression in CD4+CD25- conventional (Tconv) and CD4+CD25+ regulatory T (Treg) cells

Project description:miRNA expression profiling in highly purified murine CD4+ Tconv and Treg cells. FoxP3-GFP-hCre1a(high) reporter mice were used to separate both populations based on surface markers and presence or absence of GFP. Two-condition experiment, Tconv vs. Treg. Biological replicates: 1 Tconv, 1 Treg, purified from the same pooled mice. One replicate on 1 array.

2013-06-06 | E-GEOD-30847 | biostudies-arrayexpress

Treg cell gene expression signature in B16 melanoma

Project description:Gene expression signature of Treg cells in B16 melanoma was measured and compared to B16-infiltrating CD4+ Tconv cells and CD8+ T cells as well as splenic Treg cells, CD4+ Tconv cells and CD8+ T cells.

2016-10-31 | GSE87335 | GEO

Lkb1 maintains Treg cell lineage identity.

Project description: Not available

| S-EPMC5481770 | biostudies-literature