Transcriptomics,Genomics

Dataset Information

65

Differentially expressed genes after miRNA or siRNA transfection in human cancer cell lines (III)


ABSTRACT: To identify differentially expressed genes by anti cancer treatments (microRNAs or siRNAs) in human cancer, several cell lines (pancreatic cancer, esophageal cancer, tongue squamous cell carcinoma, hypopharyngeal squamous cell carcinoma and lung squamous cell carcinoma) were subjected to Agilent whole genome microarrays. Overall design: Human cell lines (Panc-1, SW1990, TE8, TE9, SAS, FaDu and EBC-1) were treated with miRNAs (miR-216b-3p, miR-145-5p, miR-145-3p, miR-150-5p and miR-150-3p), siRNAs (si-ZFP36L2, si-MMP13, si-TPD52, and si-MTDH).

INSTRUMENT(S): Agilent-072363 SurePrint G3 Human GE v3 8x60K Microarray 039494 [Feature Number Version]

SUBMITTER: Naohiko Seki  

PROVIDER: GSE82108 | GEO | 2016-06-03

SECONDARY ACCESSION(S): PRJNA324180

REPOSITORIES: GEO

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Publications

Regulation of TPD52 by antitumor microRNA-218 suppresses cancer cell migration and invasion in lung squamous cell carcinoma.

Kumamoto Tomohiro T   Seki Naohiko N   Mataki Hiroko H   Mizuno Keiko K   Kamikawaji Kazuto K   Samukawa Takuya T   Koshizuka Keiichi K   Goto Yusuke Y   Inoue Hiromasa H  

International journal of oncology 20160913 5


The development of targeted molecular therapies has greatly benefited patients with lung adenocarcinomas. In contrast, these treatments have had little benefit in the management of lung squamous cell carcinoma (lung SCC). Therefore, new treatment options based on current genomic approaches are needed for lung SCC. Aberrant microRNA (miRNA) expression has been shown to promote lung cancer development and aggressiveness. Downregulation of microRNA-218 (miR-218) was frequently observed in our miRNA  ...[more]

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