Transcriptomics,Genomics

Dataset Information

25

PAX7 is a required target for microRNA-206-induced differentiation of fusion-negative rhabdomyosarcoma


ABSTRACT: Genes regulated by miR-206 were identified by microarray analysis in RD cells transfected with a Negative Control (NC) or miR-206 Mimic Overall design: Human RD rhabdomyosarcoma cells were transfected with a Negative Control (NC) miRNA Mimic or a miR-206 miRNA Mimic, 48 hours post transfection RNA was extracted and hybridized on Affymetrix microarrays.

INSTRUMENT(S): [HuGene-2_0-st] Affymetrix Human Gene 2.0 ST Array [transcript (gene) version]

SUBMITTER: Yong-Dong Wang  

PROVIDER: GSE82129 | GEO | 2016-06-16

SECONDARY ACCESSION(S): PRJNA324106

REPOSITORIES: GEO

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Publications

PAX7 is a required target for microRNA-206-induced differentiation of fusion-negative rhabdomyosarcoma.

Hanna J A JA   Garcia M R MR   Go J C JC   Finkelstein D D   Kodali K K   Pagala V V   Wang X X   Peng J J   Hatley M E ME  

Cell death & disease 20160609 6


Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma of childhood. RMS can be parsed based on clinical outcome into two subtypes, fusion-positive RMS (FP-RMS) or fusion-negative RMS (FN-RMS) based on the presence or absence of either PAX3-FOXO1 or PAX7-FOXO1 gene fusions. In both RMS subtypes, tumor cells show histology and a gene expression pattern resembling that of developmentally arrested skeletal muscle. Differentiation therapy is an attractive approach to embryonal tumors of child  ...[more]

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