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MLL-EB1 fusion immortalized murine bone marrow cells

ABSTRACT: Background: MLL (KMT2A)-EB1 (MAPRE1) fusion was identified in a patient with de novo pro-B acute lymphoblastic leukemia. To investigate the leukemogenesis of MLL-EB1 fusion, a retroviral transduction of MLL-EB1 to murine bone marrow cells was performed. A frequent MLL fusion, MLL-AF10(OM-LZ), was used as a positive control. Results: Two MLL-EB1 immortalized cell lines (ME1 and ME2G), and a MLL-AF10(OM-LZ) immortalized cell line (12G) were generated. Microarray results showed that many genes including Evi1 and Ets1 were differentially expressed in ME1/ME2G and 12G cell lines.

ORGANISM(S): Mus musculus

PROVIDER: GSE82156 | GEO | 2017/06/02

SECONDARY ACCESSION(S): PRJNA324228

REPOSITORIES: GEO

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Genome wide mapping of histone 3 lysine 79 mono, di and trimethylation and histone 3 lysine 27 trimethylation in LSKs, GMPs and retroviral MLL-AF9 driven murine leukemias

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2014-09-08 | E-GEOD-55038 | biostudies-arrayexpress

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2014-09-08 | GSE55038 | GEO

Mus musculus

Project description:MLL-EB1 fusion immortalized murine bone marrow cells

| PRJNA324228 | ENA

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RNA_seq Analysis of Murine Leukemias for Identifying Potential Leukemia Fusion Targets and JAK1 regulated genes

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