Ontology highlight
ABSTRACT:
INSTRUMENT(S): Illumina HiSeq 2000 (Homo sapiens)
SUBMITTER: Robert Coffey
PROVIDER: GSE82236 | GEO | 2017-08-30
SECONDARY ACCESSION(S): PRJNA324412
REPOSITORIES: GEO
Action | DRS | |||
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GSE82236_RNAseq_counts.txt.gz | Txt | |||
GSE82236_miRNA_counts.txt.gz | Txt |
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Lu Yuanyuan Y Zhao Xiaodi X Liu Qi Q Li Cunxi C Graves-Deal Ramona R Cao Zheng Z Singh Bhuminder B Franklin Jeffrey L JL Wang Jing J Hu Huaying H Wei Tianying T Yang Mingli M Yeatman Timothy J TJ Lee Ethan E Saito-Diaz Kenyi K Hinger Scott S Patton James G JG Chung Christine H CH Emmrich Stephan S Klusmann Jan-Henning JH Fan Daiming D Coffey Robert J RJ
Nature medicine 20171016 11
De novo and acquired resistance, which are largely attributed to genetic alterations, are barriers to effective anti-epidermal-growth-factor-receptor (EGFR) therapy. To generate cetuximab-resistant cells, we exposed cetuximab-sensitive colorectal cancer cells to cetuximab in three-dimensional culture. Using whole-exome sequencing and transcriptional profiling, we found that the long non-coding RNA MIR100HG and two embedded microRNAs, miR-100 and miR-125b, were overexpressed in the absence of kno ...[more]