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HEK293 cells overexpressing HNF4a2 wild type or mutant forms C106R or R154X

ABSTRACT: Identification of genes regulated by the transcription factor HNF4a2 Keywords: ordered

ORGANISM(S): Homo sapiens

PROVIDER: GSE8289 | GEO | 2008/06/20

SECONDARY ACCESSION(S): PRJNA101255

REPOSITORIES: GEO

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HEK293 cells overexpressing wild type HNF4a2 or mutant forms HNF4a2 C106R or HNF4a2 R154X

Project description:Analysis of gene expression in human embryonic kidney cells HEK293 overexpressing the transcription factors HNF4a2 or mutant forms HNF4a2 C106R and HNF4a2 R154X, which were introduced by FRT/FLP recombination. The analysis was performed 24 hours following 1µg/ml tetracycline treatment to induce the expression of the genes. Results identify HNF4a regulated genes in kidney cells being several of these genes deregulated in renal cell carcinoma. Keywords = HEK293 embryonic kidney cells Keywords = HNF4a2 Keywords = tetracycline Keywords = FRT Keywords: ordered

2005-07-21 | GSE2700 | GEO

Transcription profiling of human HEK293 cells overexpressing HNF4a2 wild type or mutant forms C106R or R154X

Project description:Identification of genes regulated by the transcription factor HNF4a2 Experiment Overall Design: We used microarrays to identify genes regulated by the transcription factor HNF4a2. HEK293 cell lines containing doxycyclin-inducible wilt type or mutant forms of HNF4a2m which were introduced by FRT/FLP mediated recombination into FLP-In T-REx 293 cells (Invitrogen) were treated for 24 hours with 1 Âµg/ml doxycyclin. Gene expression profiles of induced and noninduced cells were compared to identify HNF4 regulated targets.

2008-10-18 | E-GEOD-8289 | biostudies-arrayexpress

Transcription profiling of human embryonic kidney cells HEK293 overexpressing the transcription factors HNF4a2 or mutant forms HNF4a2 C106R and HNF4a2 R154X to identify HNF4a regulated genes in kidney cells being several of these genes deregulated in renal cell carcinoma

Project description:Analysis of gene expression in human embryonic kidney cells HEK293 overexpressing the transcription factors HNF4a2 or mutant forms HNF4a2 C106R and HNF4a2 R154X, which were introduced by FRT/FLP recombination. The analysis was performed 24 hours following 1sg/ml tetracycline treatment to induce the expression of the genes. Results identify HNF4a regulated genes in kidney cells being several of these genes deregulated in renal cell carcinoma.<br><br>Note that files GSM52180.txt and GSM52184.txt as downloaded from GEO are identical.

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Porphyromonas gingivalis: Control (Wild-type W83) vs. its htrA mutant

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Targets of HNF1b, HNF4a2 and HNF6 in INS-1 cells

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Differentially expressed cellular genes in non-tumorigenic and tumorigenic HPV18 positive HeLa x fibroblast hybrid cells

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