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Changes in chromatin accessibility assocaiated with CD8 T cell responses to viral infections

ABSTRACT: The goal of this study was to identify the molecular programming using ATAC-seq of CD8 T cells responding to different viral infections. Mice were infected with either LCMV Armstrong to model an acute infection or LCMV Clone-13 to model a chronic infection. At various time points following infection, virus-specific CD8 T cells were purified and ATAC-seq performed. These data identify the changes in chromatin accessibility associated with acute infections and the establishment of functional memory versus those accessibility changes associated with chronic infection.

ORGANISM(S): Mus musculus

PROVIDER: GSE83081 | GEO | 2017/01/31

SECONDARY ACCESSION(S): PRJNA325011

REPOSITORIES: GEO

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