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Transcription profile of WT and LKB1 (encoded by the gene Stk11)-deficient Treg cells

ABSTRACT: LKB1 deficiency in Treg cells impairs their survival, metabolism and suppressive function. To exclude the impact of excessive inflammation on LKB1-deficient Treg cells, we generated mixed bone marrow (BM) chimeras using Foxp3-Cre WT and Foxp3-Cre Stk11 fl/fl BM cells, together with CD45.1+ BM cells. We used microarray to compare the global transcription profile of dornor-derived LKB1-deficient Tregs with WT counterparts.

ORGANISM(S): Mus musculus

PROVIDER: GSE83088 | GEO | 2017/08/29

SECONDARY ACCESSION(S): PRJNA324713

REPOSITORIES: GEO

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