Transcriptomics,Genomics

Dataset Information

51

Gene expression profile of calcified bicuspid, tricuspid and normal human aortic valves


ABSTRACT: The objective of this study was to identify genes differentially expressed between calcified bicuspid aortic valves (BAV) and tricuspid valves with (TAVc) and without (TAVn) aortic valve stenosis. Ten human BAV and nine TAVc were collected from male who underwent primary aortic valve replacement. Eight TAVn were obtained from male who underwent heart transplantation. mRNA levels were measured using Illumina HumanHT-12 v4 Expression BeadChip and compared between valve groups. Overall design: Gene expression was performed in three groups of human aortic valves including 10 calcified bicuspid aortic valves, 9 stenotic tricuspid valves and 8 tricuspid normal valves. A total of 27 samples are included in this dataset.

INSTRUMENT(S): Illumina HumanHT-12 V4.0 expression beadchip

SUBMITTER: Yohan Bossé  

PROVIDER: GSE83453 | GEO | 2016-09-22

SECONDARY ACCESSION(S): PRJNA325946

REPOSITORIES: GEO

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Publications

RNA expression profile of calcified bicuspid, tricuspid, and normal human aortic valves by RNA sequencing.

Guauque-Olarte Sandra S   Droit Arnaud A   Tremblay-Marchand Joël J   Gaudreault Nathalie N   Kalavrouziotis Dimitri D   Dagenais Francois F   Seidman Jonathan G JG   Body Simon C SC   Pibarot Philippe P   Mathieu Patrick P   Bossé Yohan Y  

Physiological genomics 20160805 10


The molecular mechanisms leading to premature development of aortic valve stenosis (AS) in individuals with a bicuspid aortic valve are unknown. The objective of this study was to identify genes differentially expressed between calcified bicuspid aortic valves (BAVc) and tricuspid valves with (TAVc) and without (TAVn) AS using RNA sequencing (RNA-Seq). We collected 10 human BAVc and nine TAVc from men who underwent primary aortic valve replacement. Eight TAVn were obtained from men who underwent  ...[more]

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