Genomics

Dataset Information

39

Differential gene expression in lymph nodes from rhesus macaque subject to unstable social condition vs. control


ABSTRACT: Differences in lymph node gene expression profiles between animals in stable vs. unstable social conditions Overall design: Gene expression profiling was carried out on lymph node mRNA samples collected from 5 animals subject to unstable social conditions and 5 animals subject to stable social conditions. The primary research question is whether gene expression differs in lymph nodes from animals exposed to unstable social conditions vs. stable social conditions.

INSTRUMENT(S): Illumina HumanRef-8 v3.0 [gene-centered version]

ORGANISM(S): Macaca Mulatta

SUBMITTER: Katie Chun  

PROVIDER: GSE83629 | GEO | 2016-12-30

SECONDARY ACCESSION(S): PRJNA326524

REPOSITORIES: GEO

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Publications

Social regulation of the lymph node transcriptome in rhesus macaques (Macaca mulatta).

Chun K K   Capitanio J P JP   Lamkin D M DM   Sloan E K EK   Arevalo J M G JM   Cole S W SW  

Psychoneuroendocrinology 20161114


Previous research has shown that adverse social conditions may promote a conserved transcriptional response to adversity (CTRA) involving up-regulation of proinflammatory gene expression and down-regulation of Type I interferon anti-viral genes in circulating blood cells. However, the impact of social conditions on lymphoid tissue gene regulation remains largely unexplored. This project assessed how social instability in adult male rhesus macaques (N=10, 5 in unstable, and 5 in stable social con  ...[more]

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