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Perturbation of epigenetic processes by doxorubicin in the mouse testes: microRNA analysis

ABSTRACT: microRNA profiling of mouse testis comparing treatment with doxorubicin to vehicle only control (published in Toxicology Research, DOI: 10.1039/C6TX00078A)

ORGANISM(S): Mus musculus

PROVIDER: GSE83661 | GEO | 2016/06/24

SECONDARY ACCESSION(S): PRJNA326666

REPOSITORIES: GEO

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Perturbation of epigenetic processes by doxorubicin in the mouse testes: mRNA analysis

Project description:mRNA profiling of mouse testis comparing treatment with doxorubicin to vehicle only control (published in Toxicology Research, DOI: 10.1039/C6TX00078A)

2016-08-04 | GSE85140 | GEO

Perturbation of epigenetic processes by doxorubicin in the mouse testes: microRNA analysis

Project description:microRNA profiling of mouse testis comparing treatment with doxorubicin to vehicle only control (published in Toxicology Research, DOI: 10.1039/C6TX00078A) Two-condition experiment, doxorubicin vs control at 3 time points (1wk, 4wk and 7 wk following treatment). Biological replicates: 12 control, 12 doxorubicin (implementing a dye swap design of n=6 forward and n=6 reverse). One replicate per dual colour array (total of 36 arrays).

2016-06-24 | E-GEOD-83661 | biostudies-arrayexpress

Perturbation of epigenetic processes by doxorubicin in the mouse testes: mRNA analysis

Project description:mRNA profiling of mouse testis comparing treatment with doxorubicin to vehicle only control (published in Toxicology Research, DOI: 10.1039/C6TX00078A) Two-condition experiment, doxorubicin vs control at 3 time points (1wk, 4wk and 7 wk following treatment). Biological replicates: 6 control, 6 doxorubicin (implementing a dye swap design of n=3 forward and n=3 reverse). One replicate per dual colour array, which consists of two slides (total of 18 arrays and 36 slides/raw data files).

2016-08-04 | E-GEOD-85140 | biostudies-arrayexpress

ATACseq of FHSD iPSC control vs doxorubicin

Project description:FSHD iPSC and TP53 KO FSHD iPSC were treated with vehicle or doxorubicin and then harvested for ATACseq

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Mouse cardiac tissues treated with doxorubicin and DMNQ

Project description:This SuperSeries is composed of the following subset Series: GSE17823: Mouse cardiac tissue, polysomes and monosomes: Vehicle treated control vs. 15mg/kg doxorubicin GSE17826: Mouse cardiac tissue: Vehicle treated control vs. 15mg/kg doxorubicin GSE17830: Mouse cardiac tissue, polysomes and monosomes: Vehicle treated control vs. 25mg/kg DMNQ GSE17915: Mouse cardiac tissue: Vehicle treated control vs. 25mg/kg DMNQ Refer to individual Series

2010-08-05 | E-GEOD-18459 | biostudies-arrayexpress

Perturbation of epigenetic processes by doxorubicin in the mouse testis.

Project description: Not available

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Effects on gene expression of doxorubicin in human stem cells-derived cardiomyocytes

Project description:To gain into the molecular mechanisms and pathways involved in doxorubicin induced cardiotoxicity, we performed whole genome transcriptome profiling via RNA-seq in hESCs-derived CMs treated with doxorubicin or vehicle only control. Cells were treated with 0, 1 or 2.5 μM of doxorubicin for 16 hours and RNA was isolated for high throughput sequencing

2018-02-21 | GSE106297 | GEO

Gene expression of cardiomyocytes isolated from vehicle and Doxorubicin challenged mice

Project description:The goal of this study was to identify differentially expressed genes in cardiomyocytes isolated from vehicle and Doxorubicin treated mice

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Gene expression in the wildtype and top2b-deleted cardiomyocytes with or without doxorubicin treatment

Project description:To compare expression profiles in the cardiomyocytes with wild type top2b and those with top2b deletion after in vivo treatment of mice with doxorubicin or drug vehicle Doxorubicin is widely used in modern cancer treatments, despite the advent of targeted therapy. However, a dose-dependent cardiotoxicity often limits its clinical use. The prevailing theory hypothesizes that doxorubicin-induced cardiotoxicity is the result of reactive oxygen species (ROS) generation due to redox-cycling of doxorubicin. Here we showed that cardiomyocyte-specific deletion of Topoisomerase II beta (Top2b) markedly reduced DNA double-strand breaks, apoptosis, and functional damages in doxorubicin-treated hearts. To investigate transcriptomic changes after doxorubicin treatment in wild type mouse and mouse with cardiac specific deletion of Top2b, we examined the expression profiles in 4 groups of mice (3/group), ie. wildtype mice with or without doxorubicin treatment and mice with Top2b deletion in the cardiomyocytes with or without doxorubicin treatment. Mice were treated with doxorubicin (25mg/kg, i.p.) or PBS (drug vehicle) for 16 hr or 72 hr. The heart was removed and cardiomyocytes were isolated by using a Langendorff apparatus. After purification, total RNA was extracted from the cardiomyocytes, purified, and used for gene expression analysis. Compared with that in control cardiomyocytes or cardiomyocytes with Top2b deletion, doxorubicin caused a significant expression change in the genome of cardiomyocytes from the wildtype mice. Among the changes, multiple genes encoding mitochondrial structural protein and components of the respiratory chain complexes were down-regulated 72 hr after treatment while multiple genes in the p53 pathway were up-regulated 16 hr after treatment in the wildtype cardiomyocytes.

2012-10-28 | GSE40289 | GEO

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