Transcriptomics,Genomics

Dataset Information

36

PP2A mediates malignant pre-B cell survival through Lineage-Specific control of cellular redox homeostasis


ABSTRACT: Ppp2r1afl/fl mouse bone marrow pre-B cells were transduced with an BCR-ABL1 vector. The BCR-ABL1 transduced Ppp2r1afl/fl pre-B cells were then transduced with an empty vector (EV), or a Cre vector for Cre-mediated PP2A deletion. Effect of PP2A deletion in the BCR-ABL1 pre-B cells were studied by Affymetrix GeneChip Mouse Genome ST1.0 Array Overall design: BCR-ABL1 transduced Ppp2r1afl/fl mice bone marrow pre-B cells were tranduced with an empty vector (EV) or a Cre vector for PP2A deletion

INSTRUMENT(S): [MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [transcript (gene) version]

SUBMITTER: Huimin Geng  

PROVIDER: GSE83742 | GEO | 2018-02-12

REPOSITORIES: GEO

altmetric image

Publications


B cell activation during normal immune responses and oncogenic transformation impose increased metabolic demands on B cells and their ability to retain redox homeostasis. While the serine/threonine-protein phosphatase 2A (PP2A) was identified as a tumor suppressor in multiple types of cancer, our genetic studies revealed an essential role of PP2A in B cell tumors. Thereby, PP2A redirects glucose carbon utilization from glycolysis to the pentose phosphate pathway (PPP) to salvage oxidative stress  ...[more]

Similar Datasets

2015-02-08 | E-GEOD-59332 | ArrayExpress
| GSE36543 | GEO
2011-08-23 | E-GEOD-24814 | ArrayExpress
| GSE24814 | GEO
2014-04-24 | E-GEOD-53684 | ArrayExpress
| GSE40836 | GEO
2013-06-03 | E-GEOD-34829 | ArrayExpress
2013-06-03 | E-GEOD-34830 | ArrayExpress
2013-06-03 | E-GEOD-34834 | ArrayExpress
| GSE34834 | GEO