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DH06 Adrenal ACTH Sus scrofa

ABSTRACT: Large White and Meishan pigs were either non-treated or injected with mammalian 1-24 ACTH (Immediate Synachten, Novartis France) at the dose of 250 µg per animal. Pigs were sacrificed either immediately after capture from their home cage (non-treated animals) or 1 hour following ACTH injection. Adrenal glands were immediately collected from pigs and frozen on dry ice and then stored at -80°C until RNA isolation. Keywords: stress response, adrenal, gene expression, pig

ORGANISM(S): Sus scrofa

PROVIDER: GSE8377 | GEO | 2008/01/07

SECONDARY ACCESSION(S): PRJNA101413

REPOSITORIES: GEO

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DH06 Adrenal ACTH Sus scrofa

Project description:Large White and Meishan pigs were either non-treated or injected with mammalian 1-24 ACTH (Immediate Synachten, Novartis France) at the dose of 250 Âµg per animal. Pigs were sacrificed either immediately after capture from their home cage (non-treated animals) or 1 hour following ACTH injection. Adrenal glands were immediately collected from pigs and frozen on dry ice and then stored at -80Â°C until RNA isolation. Keywords: stress response, adrenal, gene expression, pig 47 samples

2010-06-29 | E-GEOD-8377 | biostudies-arrayexpress

Sus scrofa

Project description:DH06 Adrenal ACTH Sus scrofa

| PRJNA101413 | ENA

Time course of the response to ACTH in pig: biological and transcriptomic study

Project description:To explore individual variation in the biological response to cortisol, the main stress hormone, in pigs, we have developed a microarray analysis to study the kinetics of the response to an ACTH injection measured at 4 time points. ACTH is a hormone secreted by the pituitary gland and triggering the release of cortisol by the adrenal glands in response to a stress. The objective was to identify genes up- or down-regulated during the stress response triggered by cortisol in the whole blood.

2015-07-23 | GSE71207 | GEO

Expression data from Sus scrofa atria

Project description:Regulatory Mechanisms of Atrial Remodeling of Mitral Regurgitation Pigs This study enrolled 6 pigs (age: 18 months) and divided into three groups: mitral regurgitation pigs (MR) (n = 2; 2 males sacrificed 12 months after surgery), MR pigs treated with valsartan (MRV) (n = 2; 2 males age-matched to MR sacrificed 12 months after surgery), and normal control pigs (NC) (n = 2; 2 males age-matched to MR pigs). Valsartan (3.43 mg/kg/day), a type I angiotensin II receptor blocker, was administered from one week before surgery and then daily after surgery in the MRV group. We sought to systemically elucidate critical differences in the alteration of RNA expression pattern between the atrial myocardium of pigs with and without MR, and between the atrial myocardium of MR pigs with and without valsartan using high-density oligonucleotide microarrays and functional network enrichment analysis.

2015-02-01 | E-GEOD-43072 | biostudies-arrayexpress

Sus scrofa

Project description:Expression data from longissimus dorsi muscle of Meishan pigs

| PRJNA132261 | ENA

Expression data from Sus scrofa ventricle

Project description:Regulatory Mechanisms of complete AV-block Pigs

2019-03-19 | GSE112065 | GEO

Expression data from Sus scrofa atria

Project description:Regulatory Mechanisms of Atrial Remodeling of Mitral Regurgitation Pigs

2015-02-01 | GSE43072 | GEO

ACTH-independent macronodular adrenocortical hyperplasia (AIMAH)

Project description:ACTH-independent macronodular adrenal hyperplasia (AIMAH) is a clinically and genetically heterogeneous disorder that can be associated with aberrant hormone receptors. Whole-genome expression profiling was analyzed in samples of different nodules from a patient with AIMAH. Total RNA obtained from adrenal nodules were compared to those samples obtained normal adrenal pools

2010-10-30 | E-GEOD-25031 | biostudies-arrayexpress

Genome-wide analysis of adult adrenocortical cells gene expression after 48 h ACTH treatment

Project description:Analysis of ACTH-regulation on adrenocortical cells at gene expression level. The hypothesis tested in the present study was that ACTH increases chronic cell growth and steroidogenesis in adrenal glands by changing the gene expression profile. Results provide important information of the response of adrenocortical cells gene expression to chronic ACTH treatment. Total RNA obtained from primary cultured adult adrenal cells subjected to 48 hours in vitro treatment of ACTH compared to untreated control cell.

2010-07-08 | E-GEOD-20669 | biostudies-arrayexpress

Genome-wide analysis of fetal adrenocortical cells gene expression after 48 h ACTH treatment

Project description:Analysis of ACTH-regulation on adrenocortical cells at gene expression level. The hypothesis tested in the present study was that ACTH increases chronic cell growth and steroidogenesis in adrenal glands by changing the gene expression profile. Results provide important information on the changes of gene expression of adrenocortical cells after chronic ACTH treatment. Total RNA obtained from primary cultured fetal adrenal cells subjected to 48 hours in vitro treatment of ACTH compared to untreated control cell.

2010-07-08 | E-GEOD-20675 | biostudies-arrayexpress

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