Genomics

Dataset Information

38

Histone Deacetylase 3 Prepares Brown Adipose Tissue For Acute Thermogenic Challenge


ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Overall design: Refer to individual Series

INSTRUMENT(S): Illumina HiSeq 2000 (Mus musculus)

SUBMITTER: Hee-Woong Lim 

PROVIDER: GSE83928 | GEO | 2017-06-14

SECONDARY ACCESSION(S): GSE83926 GSE83927S-EPMC5826652PRJNA327418

REPOSITORIES: GEO

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Publications


Brown adipose tissue is a thermogenic organ that dissipates chemical energy as heat to protect animals against hypothermia and to counteract metabolic disease. However, the transcriptional mechanisms that determine the thermogenic capacity of brown adipose tissue before environmental cold are unknown. Here we show that histone deacetylase 3 (HDAC3) is required to activate brown adipose tissue enhancers to ensure thermogenic aptitude. Mice with brown adipose tissue-specific genetic ablation of HD  ...[more]

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