Transcriptomics,Genomics

Dataset Information

136

Genome-wide Identification of Neuronal Activity-regulated Genes in Drosophila [DA_PDF]


ABSTRACT: We identified ARGs in a genome-wide manner, in fly brains as well as in sorted neurons; they included dopaminergic neurons (DA) and a subset of circadian-related neurons (PDF+ neurons). Overall design: TH-GAL4 (DA neurons)/PDF-gal4 (PDF+ cells);UAS-TrpA1 or TH-GAL4 flies stimulated with temperature shift and mRNA isolated and sequenced 0 or 60 min after.

REANALYSED by: GSE117217

INSTRUMENT(S): Illumina HiSeq 1000 (Drosophila melanogaster)

SUBMITTER: Xiao Chen  

PROVIDER: GSE83969 | GEO | 2016-12-12

SECONDARY ACCESSION(S): PRJNA327578

REPOSITORIES: GEO

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Publications

Genome-wide identification of neuronal activity-regulated genes in Drosophila.

Chen Xiao X   Rahman Reazur R   Guo Fang F   Rosbash Michael M  

eLife 20161209


Activity-regulated genes (ARGs) are important for neuronal functions like long-term memory and are well-characterized in mammals but poorly studied in other model organisms like Drosophila. Here we stimulated fly neurons with different paradigms and identified ARGs using high-throughput sequencing from brains as well as from sorted neurons: they included a narrow set of circadian neurons as well as dopaminergic neurons. Surprisingly, many ARGs are specific to the stimulation paradigm and very sp  ...[more]

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