Transcriptomics,Genomics

Dataset Information

162

Genome-wide Identification of Neuronal Activity-regulated Genes in Drosophila [KCl]


ABSTRACT: We identified ARGs in a genome-wide manner, in fly brains as well as in sorted neurons; they included dopaminergic neurons (DA) and a subset of circadian-related neurons (PDF+ neurons). Overall design: KCl stimulation of dissected brains and mRNA isolated and sequenced 0, 15, 30, 60 min after.

REANALYSED by: GSE117217

INSTRUMENT(S): NextSeq 550 (Drosophila melanogaster)

SUBMITTER: Xiao Chen  

PROVIDER: GSE83974 | GEO | 2016-12-12

SECONDARY ACCESSION(S): PRJNA327582

REPOSITORIES: GEO

altmetric image

Publications

Genome-wide identification of neuronal activity-regulated genes in Drosophila.

Chen Xiao X   Rahman Reazur R   Guo Fang F   Rosbash Michael M  

eLife 20161209


Activity-regulated genes (ARGs) are important for neuronal functions like long-term memory and are well-characterized in mammals but poorly studied in other model organisms like Drosophila. Here we stimulated fly neurons with different paradigms and identified ARGs using high-throughput sequencing from brains as well as from sorted neurons: they included a narrow set of circadian neurons as well as dopaminergic neurons. Surprisingly, many ARGs are specific to the stimulation paradigm and very sp  ...[more]

Similar Datasets

| GSE83969 | GEO
| GSE83973 | GEO
| GSE83975 | GEO
| GSE83970 | GEO
| GSE99253 | GEO
2014-03-01 | E-GEOD-55475 | ArrayExpress
| GSE115070 | GEO
2009-05-10 | E-GEOD-15920 | ArrayExpress
2009-05-10 | GSE15920 | GEO
2011-07-04 | GSE27174 | GEO