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Genome-wide profiling of cardiac H3K9me2 levels in response to ischemic preconditioning

ABSTRACT: H3K9me2 ChIP-Seq of cardiac biopsies from the area at risk and remote myocardium of mice subjected to ischemic preconditioning.

ORGANISM(S): Mus musculus

PROVIDER: GSE83979 | GEO | 2016/07/04

SECONDARY ACCESSION(S): PRJNA327592

REPOSITORIES: GEO

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Genome-wide profiling of cardiac H3K9me2 levels in response to ischemic preconditioning

Project description:H3K9me2 ChIP-Seq of cardiac biopsies from the area at at risk and remote myocardium of mice subjected to ischemic preconditioning. Mice were subjected to ischemic preconditioning (IPC) through reversible ligation of the left coronary artery or a sham procedure. The procedure consisted of 5 minutes of ischemia followed by 5 minutes of reperfusion, repeated 4 times and then followed by a 30 minute reperfusion period. Biopsies were taken from the area at risk (AAR) and remote myocardium (RM) from six IPC mice

2016-07-04 | E-GEOD-83979 | biostudies-arrayexpress

Transcriptomic profiling of cardiac biopsies from mice subjected to ischemic preconditioning

Project description:Microarray profiling of cardiac biopsies from the area at at risk and remote myocardium of mice subjected to ischemic preconditioning. Mice were subjected to ischemic preconditioning (IPC) through reversible ligation of the left coronary artery or a sham procedure. The procedure consisted of 4 minutes of ischemia followed by 4 minutes of reperfusion, repeated 4 times and then followed by a 30 minute reperfusion period. Biopsies were taken from the area at risk (AAR) and remote myocardium (RM) from two IPC mice and two sham control mice.

2016-06-24 | E-GEOD-83659 | biostudies-arrayexpress

Transcriptomic profiling of cardiac biopsies from mice subjected to ischemic preconditioning

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Transcriptional profile of sustained ligand-activated preconditioning in pre- and post-ischemic myocardium

Project description:Analysis of left venticular myocardium following morphine-induced sustained ligand activated preconditioning (SLP). Results provide insight into the molecular pathways affected by morphine-induced SLP in the pre- and post-ischemic heart. Total RNA obtained from isolated ventricular myocardium subjected to 5 days of morphine induced sustained ligand activated preconditioning (SLP) compared to placebo control ventricular myocardium, tissue collected pre- and post-ischemia (n=6/group).

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Attenuated inflammatory profile following single and repeated handgrip exercise and remote ischemic preconditioning in patients with cerebral small vessel disease

Project description:Similar to remote ischemic preconditioning bouts of exercise may possess immediate protective effects against ischemia-reperfusion injury. However, underlying mechanisms are largely unknown. This study compared the impact of single and repeated handgrip exercise versus remote ischemic preconditioning on inflammatory biomarkers in patients with cerebral small vessel disease (cSVD). In this crossover study, 14 patients with cSVD were included. All participants performed 4-days of handgrip exercise (4x5-minutes at 30% of maximal handgrip strength) and remote ischemic preconditioning (rIPC; 4x5-minutes cuff occlusion around the upper arm) twice daily. Patients were randomized to start with either handgrip exercise or rIPC and the two interventions were separated by >9 days. Venous blood was drawn before and after one intervention, and after 4-days of repeated exposure. We performed a targeted proteomics on inflammation markers in all blood samples.

2023-03-11 | PXD037267 | Pride

Transcriptional profile of sustained ligand-activated preconditioning in pre- and post-ischemic myocardium

2012-10-01 | GSE39407 | GEO

The analysis of differential gene expression after remote ischemic preconditioning of renal ischemia reperfusion injury

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Project description:In this placebo-controlled randomized controlled trial, we tested whether remote ischemic preconditioning (RIPC) elicited by four 5-minute cycles of 300 mmHg of cuff inflation/deflation of the lower limb would reduce myocardial necrosis in isoflurane-anesthetized patients undergoing on-pump coronary artery bypass graft surgery. Secondary outcomes were the perioperative release of the biomarkers NTproBNP, hsCRP, S100, atrial transcriptional profiles, and short- and long-term clinical outcomes. RIPC with concomitantly applied isoflurane did not affect the release of biomarkers or clinical outcome. NTproBNP release correlated with isoflurane- but not RIPC-induced transcriptional changes.

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