Dataset Information


Gene expression profile in the small Maf-deficient livers.

ABSTRACT: To elucidate the functional roles of sMafs in the adult liver, we conditionally targeted the sMaf genes using a transgenic complementation rescue approach. MafF-/-::MafG-/-::MafK-/- (F0G0K0) mice are embryonic lethal but can be rescued by complementation of transgenic MafG expression under the regulation of the MafG regulatory domain (MGRD). Therefore, we rescued F0G0K0 mice using a MGRD transgenic mouse line with a MafG gene flanked with loxP (fMafG) sequences so that the MafG gene could be deleted by Cre-mediated recombination. The Albumin(Alb)-Cre transgenic mice were used to delete fMafG gene specifically in the liver. The genotype used are MafF-/-::MafG-/-::MafK-/-::MGRD-fMafG::Alb-Cre (liver-specific sMaf CKO) and MafF-/-::MafG+/-::MafK-/-::MGRD-fMafG::Alb-Cre (control). Overall design: The microarray analyses were performed using three independent RNA samples from livers of liver-specific sMaf CKO and control mice at 5 weeks of age.

INSTRUMENT(S): Agilent-014868 Whole Mouse Genome Microarray 4x44K G4122F (Probe Name version)

SUBMITTER: Masayuki Yamamoto  

PROVIDER: GSE84001 | GEO | 2017-05-01



Dataset's files

Action DRS
GSE84001_RAW.tar Raw
filelist.txt Txt
Items per page:
1 - 2 of 2
altmetric image


Small Maf deficiency recapitulates the liver phenotypes of Nrf1- and Nrf2-deficient mice.

Katsuoka Fumiki F   Yamazaki Hiromi H   Yamamoto Masayuki M  

Genes to cells : devoted to molecular & cellular mechanisms 20161010 12

Nrf1 and Nrf2 (NF-E2-related factors 1 and 2, respectively) are transcription factors that belong to the Cap'n'collar (CNC) family and play critical roles in various tissues, including the liver. Liver-specific Nrf1 knockout mice show hepatic steatosis, accompanied by dysregulation of various metabolic genes. Nrf2 knockout mice show impairment in the induction of antioxidant and xenobiotic-metabolizing enzyme genes. Although it has been shown that small Maf (sMaf) proteins act as obligatory part  ...[more]

Similar Datasets

2002-01-01 | S-EPMC1222317 | BioStudies
2012-01-09 | E-GEOD-29558 | ArrayExpress
2012-01-01 | S-EPMC3272985 | BioStudies
1000-01-01 | S-EPMC231611 | BioStudies
2019-01-01 | S-EPMC6778130 | BioStudies
2019-01-01 | S-EPMC6766697 | BioStudies
2015-01-01 | S-EPMC4370457 | BioStudies
2015-01-01 | S-EPMC4486474 | BioStudies
2019-08-06 | GSE134352 | GEO
| PRJNA141327 | ENA