Early gene expression in mouse hematopoietic stem cells induced by Thrombopoietin stimulation and irradiation

ABSTRACT: Thrombopoietin (TPO) was shown to prevent irradaition-induced hematopoietic stem cells (HSCs) loss of function. A single injection of TPO to mice 45-60 min prior to irradiation is sufficient to reverse the long-lasting accumulation of persistent DNA damage. We used microarrays to analyze whether this effet can relie on TPO-induced specific transcriptional changes during this early time.

ORGANISM(S): Mus musculus

PROVIDER: GSE84195 | GEO | 2017/12/31

SECONDARY ACCESSION(S): PRJNA328265

REPOSITORIES: GEO