Transcriptomics,Genomics

Dataset Information

37

Comparison of CLL and MCL primary cells obtained from a patient with MCL variant Richter syndrome


ABSTRACT: Comparison of CLL and MCL primary cells obtained from a patient with MCL variant Richter syndrome Overall design: CLL and MCL samples are labeled CLL and MCL, respectively. This dataset contains 2 Illumina array spots with a samples of interest from the 12 spot array.

INSTRUMENT(S): Illumina HumanHT-12 V4.0 expression beadchip

SUBMITTER: Vojtěch Kulvait  

PROVIDER: GSE84286 | GEO | 2016-07-13

SECONDARY ACCESSION(S): PRJNA328592

REPOSITORIES: GEO

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Publications

Mantle cell lymphoma-variant Richter syndrome: Detailed molecular-cytogenetic and backtracking analysis reveals slow evolution of a pre-MCL clone in parallel with CLL over several years.

Klener Pavel P   Klener Pavel P   Fronkova Eva E   Berkova Adela A   Jaksa Radek R   Lhotska Halka H   Forsterova Kristina K   Soukup Jan J   Kulvait Vojtech V   Vargova Jarmila J   Fiser Karel K   Prukova Dana D   Alam Mahmudul M   Calvin Lenyeletse Maswabi Bokang B   Michalova Kyra K   Zemanova Zuzana Z   Jancuskova Tereza T   Pekova Sona S   Trneny Marek M  

International journal of cancer 20160802 10


Richter syndrome represents the transformation of the chronic lymphocytic leukemia (CLL) into an aggressive lymphoma, most frequently the diffuse large B-cell lymphoma (DLBCL). In this report we describe a patient with CLL, who developed a clonally-related pleomorphic highly-aggressive mantle cell lymphoma (MCL) after five cycles of a fludarabine-based second-line therapy for the first relapse of CLL. Molecular cytogenetic methods together with whole-exome sequencing revealed numerous gene alter  ...[more]

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