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Gene expression profiling reveals cytoplasmic U1 snRNA accumulation may cause cancers

ABSTRACT: In this study, we built a model of cytoplasmic aggregation of U1 snRNA in a rat cell line. By comparing the gene expression profiling of U1 snRNA accumulated cells with their controls, 916 (about 4% of 20,000) genes were identified significantly differentially expressed. These 595 over-expressed genes and 321 repressed genes were further analyzed by GO and KEGG pathway enrichment. As a result, three of 12 enriched pathways are well-known cancer pathways, while nine of them were associated to cancers in previous studies. These findings suggest that cytoplasmic U1 snRNA accumulation may cause cancers.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE84304 | GEO | 2016/07/13

SECONDARY ACCESSION(S): PRJNA328780

REPOSITORIES: GEO

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