Transcriptomics

Dataset Information

21

Genes in nonpermissive temperature-induced cell growth arrest and differentiation of tracheal epithelial RTEC11 cells


ABSTRACT: We performed global scale microarray analysis to identify detailed mechanisms by which nonpermissive temperature induces cell growth arrest and differentiation in tracheal epithelial RTEC11 cells harboring temperature-sensitive simian virus 40 large T-antigen by using an Affymetrix GeneChip system. Tracheal epithelial RTEC11 cells used in this study were derived from transgenic rats harboring a temperature-sensitive simian virus 40 large T-antigen. Although the cells grew continuously at the permissive temperature, the nonpermissive temperature led to cell growth arrest and differentiation. Keywords: rat tracheal epithelial RTEC11; growth arrest; differentiation; gene expression Overall design: A rat conditionally immortalized tracheal epithelial cell line, RTEC11, derived from transgenic rats harboring a temperature-sensitive simian virus 40 large T-antigen was used. RTEC11 cells were cultured at permissive (33°C) or nonpermissive (39°C) temperature for 3 days.

INSTRUMENT(S): [RAE230A] Affymetrix Rat Expression 230A Array

ORGANISM(S): Rattus norvegicus  

SUBMITTER: Yoshiaki Tabuchi  

PROVIDER: GSE8444 | GEO | 2007-07-17

SECONDARY ACCESSION(S): PRJNA101517

REPOSITORIES: GEO

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