Genomics

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Gene expression analysis of human macrophages exposed to lipoprotein lipase hydrolysis products


ABSTRACT: Lipoprotein lipase (LPL) is an extracellular lipase that preferentially hydrolyses triglycerides in triglyceride-rich lipoproteins within the circulation. LPL expression in macrophages contributes to atherosclerosis. In addition, the hydrolysis products liberated from lipoprotein lipids by LPL causes lipid accumulation and impairs cholesterol efflux ability in macrophages. However, the effects of LPL hydrolysis products in modulating the transcript profiles within macrophages and their roles in foam cell formation are not completely understood. We performed microarray analyses on THP-1 macrophages incubated with LPL hydrolysis products to identify differentially expressed genes.

ORGANISM(S): Homo sapiens

PROVIDER: GSE84791 | GEO | 2017/02/15

SECONDARY ACCESSION(S): PRJNA331149

REPOSITORIES: GEO

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