Transcriptomics,Genomics

Dataset Information

31

Long Noncoding RNA and mRNA Expression Profile in Laryngeal Squamous Cell Carcinoma


ABSTRACT: To investigate the aberrant expressed lncRNA and mRNA and identify the potential lncRNA correlated with core mRNA in LSCC, we screened lnRNA and mRNA expression profile in 9 pairs of primary Stage IV LSCC tissues and adjacent non-neoplastic tissues by lncRNA and mRNA integrated microarrays, conducted in-depth integrated bioinformatics analysis of lncRNA and mRNA, and performed qRT-PCR assays to further validate their expressions in an independent cohort of 30 pairs tissue samples Overall design: lnRNA and mRNA expression profile in 9 pairs of primary Stage IV laryngeal squamous cell carcinoma (LSCC) cancer tissues and adjacent non-neoplastic tissues by lncRNA and mRNA integrated microarrays

INSTRUMENT(S): Agilent-042818 Human lncRNA Micorarray 8_24_v2 [Probe Name version]

SUBMITTER: Lin Feng  

PROVIDER: GSE84957 | GEO | 2016-12-29

SECONDARY ACCESSION(S): PRJNA335744

REPOSITORIES: GEO

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Publications

Integrated Analysis of Long Noncoding RNA and mRNA Expression Profile in Advanced Laryngeal Squamous Cell Carcinoma.

Feng Ling L   Wang Ru R   Lian Meng M   Ma Hongzhi H   He Ning N   Liu Honggang H   Wang Haizhou H   Fang Jugao J  

PloS one 20161229 12


Long non-coding RNA (lncRNA) plays an important role in tumorigenesis. However, the expression pattern and function of lncRNAs in laryngeal squamous cell carcinoma (LSCC) are still unclear. To investigate the aberrantly expressed lncRNAs and mRNAs in advanced LSCC, we screened lncRNA and mRNA expression profiles in 9 pairs of primary Stage IVA LSCC tissues and adjacent non-neoplastic tissues by lncRNA and mRNA integrated microarrays. Gene Ontology and pathway analysis were performed to find out  ...[more]

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