The AP-1 transcription factor FOSL1 causes melanocyte reprogramming and transformation

ABSTRACT: The MAPK pathway is activated in the large majority of melanomas and is the subject of several therapeutic approaches. Under normal conditions, it quickly raises the so-called immediate early response, which encompasses the transient transcription of several genes belonging to the AP-1 transcription factor family. Under pathological conditions such as consistent MAPK pathway overactivation due to oncogenic alterations occurring in melanoma, these genes are permanently expressed. The consequences of a permanent expression of these genes are currently unknown.

ORGANISM(S): Homo sapiens

PROVIDER: GSE85086 | GEO | 2017/08/02

SECONDARY ACCESSION(S): PRJNA336110

REPOSITORIES: GEO