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CTCF modulates Estrogen Receptor function through specific chromatin and nuclear matrix interactions

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Homo sapiens

PROVIDER: GSE85108 | GEO | 2016/12/10

SECONDARY ACCESSION(S): PRJNA336182

REPOSITORIES: GEO

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CTCF modulates Estrogen Receptor function through specific chromatin and nuclear matrix interactions [ChIP-seq]

Project description:In our work we used high-throughput sequencing methods to get insight in the role of CTCF in ER-mediated gene regulation in luminal breast cancer cells. After assessing genome-wide binding of CTCF, ER, FOXA1 and Lamin B in MCF7 cells treated with estrogen for different time points, we could correlate the interaction to the chromatin with estrogen-induced de novo transcription (from GRO-seq data) and loop formation (from ChIA-PET, Fullwood et al., 2009). We observed that CTCF binding correlates with ER-mediated transcription and its depletion can affect ER-ER loop formation and subsequently gene expression.

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CTCF modulates Estrogen Receptor function through specific chromatin and nuclear matrix interactions [RNA-seq]

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CTCF modulates Estrogen Receptor function through specific chromatin and nuclear matrix interactions

Project description:CTCF modulates Estrogen Receptor function through specific chromatin and nuclear matrix interactions

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