Dataset Information


A. nidulans transcriptome analysis

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Overall design: Refer to individual Series

INSTRUMENT(S): TIGR PFGRC Aspergillus nidulans version 1 array designed primarily based on strain FGSC A4

SUBMITTER: Gustavo Henrique Goldman   

PROVIDER: GSE8529 | GEO | 2007-07-25



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Transcriptome analysis of the Aspergillus nidulans AtmA (ATM, Ataxia-Telangiectasia mutated) null mutant.

Malavazi Iran I   Savoldi Marcela M   da Silva Ferreira Márcia Eliana ME   Soriani Frederico Marianetti FM   Bonato Pierina Sueli PS   de Souza Goldman Maria Helena MH   Goldman Gustavo H GH   Goldman Gustavo H GH  

Molecular microbiology 20071001 1

ATM is a phosphatidyl-3-kinase-related protein kinase that functions as a central regulator of DNA damage response in eukaryotes. In humans, mutations in ATM cause the devastating neurodegenerative disease Ataxia-Telangiectasia. Previously, we characterized the homologue of ATM (AtmA) in the filamentous fungus Aspergillus nidulans. In addition to its expected role in the DNA damage response, we found that AtmA is also required for polarized hyphal growth. Our results suggested that AtmA probably  ...[more]