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Gene expression in alveolar macrophages between bleomycin–treated wild-type and S1pr2-/- mice.

ABSTRACT: We compared mRNA expression in alveolar macrophages between bleomycin–treated wild-type and S1pr2-/- mice, using DNA microarray analysis. In S1pr2-/- macrophages, 398 genes showed decreases to less than 50% of the levels in wild-type macrophages. In contrast, 122 genes showed more than 2.0-fold increases in S1pr2-/- macrophages compared with wild-type macrophages. The downregulated genes in S1pr2-/- mice included the following potentially fibrosis–related genes: profibrotic cytokines, chemokines, and the markers characteristic of classically activated (M1) and alternatively activated (M2) macrophages.

ORGANISM(S): Mus musculus

PROVIDER: GSE85411 | GEO | 2018/05/30

REPOSITORIES: GEO

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