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Molecular Changes in the Nasal Cavity after 5 days of N, N-dimethyl-p-toluidine Exposure

ABSTRACT: To identify nasal cavity transcripts differentially expressed due to treatment with N, N-dimethyl-p-toluidine (DMPT), we collected RNA during the from male F344/N rats exposed to 120 mg/kg DMPT, 5 days after DMPT exposure for animals 5-6 weeks of age. These samples were interrogated with the Affymetrix Rat Genome 230 2.0 GeneChip Array. A total of 2,561 gene transcripts were differentially expressed due to DMPT treatment (false discovery rate (FDR) < 0.05).

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE85454 | GEO | 2016/08/11

SECONDARY ACCESSION(S): PRJNA338495

REPOSITORIES: GEO

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Molecular Changes in the Nasal Cavity after 5 days of N, N-dimethyl-p-toluidine Exposure

Project description:To identify nasal cavity transcripts differentially expressed due to treatment with N, N-dimethyl-p-toluidine (DMPT), we collected RNA during the from male F344/N rats exposed to 120 mg/kg DMPT, 5 days after DMPT exposure for animals 5-6 weeks of age. These samples were interrogated with the Affymetrix Rat Genome 230 2.0 GeneChip Array. A total of 2,561 gene transcripts were differentially expressed due to DMPT treatment (false discovery rate (FDR) < 0.05). There were 2 groups and 5x replication for each group, for 10 total samples. The groups were (1) DMPT and (2) vehicle control. We compared vehicle control vs DMPT using ORIOGEN software. The permutation based p-values for each test were significant for FDRâ¤5%.

2016-08-11 | E-GEOD-85454 | biostudies-arrayexpress

Hepatic transcriptomic alterations for N,N-dimethyl-p-toluidine (DMPT) and p-toluidine after 5-day exposure in rats

Project description:To identify liver transcripts differentially expressed due to treatment with N, N-dimethyl-p-toluidine (DMPT) and p-toluidine, we collected RNA during the from male F344/N rats exposed to 0, 1, 6, 20, 60 or 120 mg/kg DMPT (or p-toluidine), 5 days after exposure for animals 5-6 weeks of age. These samples were interrogated with the Affymetrix Rat Genome 230 2.0 GeneChip Array. A total of 511 gene transcripts were differentially expressed due to DMPT treatment and 354 gene transcripts were differentially expressed due to p-toluidine treatment (false discovery rate (FDR) < 0.05).

2017-06-27 | GSE100502 | GEO

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Project description:Transcription profiling of mouse nasal cavity comparing control and short-term (4 weeks) or long-term (8 weeks) of DEP-exposed group.

2018-05-22 | GSE114719 | GEO

Nasal cavity epithelial cells exhibit antiviral transcriptional signatures upon activation of IFN-gamma producing antigen-specific T cells

Project description:To evaluate the differential impact of IFN-gamma secretion on nasal cavity epithelial cells, we compared the transcriptional profiles of nasal cavity epithelial cells (CD45-, CD3- CD11b-, CD31-, CD326+) from wildtype and IFN-gamma knockout mice at 30 days (d30) post intranasal infection with a live attenuated influenza virus expressing the immunodominant H-2Kd CD8 T cell epitope from Sendai virus nucleoprotein (LAIV-SenNP). Nasal cavity epithelial cells were also analyzed from LAIV-SenNP immunized wildtype and IFN-gamma knockout mice 3 days after intranasal administration of Sendai virus nucleoprotein peptide (d30+3). The results indicate that nasal cavity epithelial cells express genes associated with antigen presentation and antiviral function following antigen-specific T cell activation, and these alterations in transcriptional programming depend on IFN-gamma secretion.

2024-02-15 | GSE247376 | GEO

Oral cavity

Project description:Oral cavity Targeted loci

| PRJNA622970 | ENA

Rattus norvegicus

Project description:Molecular Changes in the Nasal Cavity after 5 days of N, N-dimethyl-p-toluidine Exposure

| PRJNA338495 | ENA

Molecular Changes in the Nasal Cavity after N, N-dimethyl-p-toluidine Exposure.

Project description: Not available

| S-EPMC5804348 | biostudies-literature

Human sinonasal cavity

Project description:Human sinonasal cavity Targeted loci environmental

| PRJNA407725 | ENA

Human oral cavity

Project description:Human oral cavity metagenome and metatranscriptome

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Peritoneal cavity macrophage response to IFNg and IFNa

Project description:We seeked to determine in vivo effects of IFNg and IFNa response in peritoneal cavity macrophages. These cells were part of ImmGen Interferon cytokine study and immunocytes were sorted according to Immgen's standard lineage panel. Profiles from peritoneal cavity macrophages were used to analyze cell specific responses to IFNg.

2018-02-14 | GSE110549 | GEO

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